When a young hiker stumbles onto an isolated farm after losing her way on the Appalachian Trail, she is taken in by a strange yet beautiful couple desperate to protect a secret deep in the mountains.

After a comet releases a mysterious virus that begins to kill all of the women in the world, a young couple's relationship is severely tested. They hide out (from both the illness and the savages who hunt the remaining women) in their over-sterilized apartment. Ultimately the duo escapes their self-imposed quarantine to head to the wilderness.